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Myocardial Failure in Cats Associated with Low Plasma Taurine: a Reversible Cardiomyopathy
Abstract
Thousands of pet cats die each year with dilated cardiomyopathy, the cause of which is unknown. Although taurine is present in millimolar concentrations in the myocardium of all mammals, taurine depletion has not previously been associated with a decrease in myocardial function in any species. In this study, low plasma taurine concentrations associated with echocardiographic evidence of myocardial failure were observed in 21 cats fed commercial cat foods and in 2 of 11 cats fed a purified diet containing marginally low concentrations of taurine for 4 years. Oral supplementation of taurine resulted in increased plasma taurine concentrations and was associated with normalization of left ventricular function in both groups of cats. Since myocardial concentrations of taurine are directly related to plasma concentrations and low plasma concentrations were found to be associated with myocardial failure in cats, a direct link between decreased taurine concentration in the myocardium and decreased myocardial mechanical function is proposed.
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Cited by
Gan, X. T., Ettinger, G., Huang, C. X., Burton, J. P., Haist, J. V., Rajapurohitam, V., Sidaway, J. E., Martin, G., Gloor, G. B., Swann, J. R., et al. (2014) · Circulation: Heart Failure · doi:10.1161/circheartfailure.113.000978 · Cited by 329
Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function
Seidel, U., Huebbe, P., & Rimbach, G. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800569 · Cited by 176
Taurine concentrations in animal feed ingredients; cooking influences taurine content
Spitze, A. R., Wong, D. L., Rogers, Q. R., & Fascetti, A. J. (2003) · Journal of Animal Physiology and Animal Nutrition · doi:10.1046/j.1439-0396.2003.00434.x · Cited by 175
Self-citationTaurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
Kaplan, J. L., Stern, J. A., Fascetti, A. J., Larsen, J. A., Skolnik, H., Peddle, G. D., Kienle, R. D., Waxman, A., Cocchiaro, M., Gunther-Harrington, C. T., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0209112 · Cited by 101
Taurine deficiency in Newfoundlands fed commercially available complete and balanced diets
Backus, R. C., Cohen, G., Pion, P. D., Good, K. L., Rogers, Q. R., & Fascetti, A. J. (2003) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2003.223.1130 · Cited by 70
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Metadata
- Authors
- Pion, P. D., Kittleson, M. D., Rogers, Q. R., & Morris, J. G.
- Venue
- Science
- Published
- 1987-08-14
- Volume
- 237
- Issue
- 4816
- Pages
- 764-768
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2136879982
- Cited by
- 500
- References
- 0
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Myocardial Failure in Cats Associated with Low Plasma Taurine: a Reversible Cardiomyopathy. https://app.cochat.ai/papers/10.1126/science.3616607
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- Pion, P. D., Kittleson, M. D., Rogers, Q. R., & Morris, J. G. (1987). Myocardial Failure in Cats Associated with Low Plasma Taurine: a Reversible Cardiomyopathy. Science. https://doi.org/10.1126/science.3616607
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
