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Cited by 1,293

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A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression

Suva, L. J., Winslow, G. A., Wettenhall, R. E. H/., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., Rodda, C. P., Kemp, B. E., Rodriguez, H., Chen, E. Y., Hudson, P. J., Martin, T. J., Wood, W. I.·1987·Science
DOI 10.1126/science.3616618
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Abstract

Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We report here the isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian cells. The clones encode a prepro peptide of 36 amino acids and a mature protein of 141 amino acids that has significant homology with parathyroid hormone in the amino-terminal region. This previously unrecognized hormone may be important in normal as well as abnormal calcium metabolism.

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Metadata

Authors
Suva, L. J., Winslow, G. A., Wettenhall, R. E. H., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., Rodda, C. P., Kemp, B. E., Rodriguez, H., Chen, E. Y., Hudson, P. J., Martin, T. J., & Wood, W. I.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1987-08-21
Volume
237
Issue
4817
Pages
893-896
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.3616618
OpenAlex
W2017211434
Cited by
1,293
References
0
FWCI
74.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression. https://app.cochat.ai/papers/10.1126/science.3616618
The paper
Suva, L. J., Winslow, G. A., Wettenhall, R. E. H., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., Rodda, C. P., Kemp, B. E., Rodriguez, H., Chen, E. Y., Hudson, P. J., Martin, T. J., & Wood, W. I. (1987). A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression. Science. https://doi.org/10.1126/science.3616618

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.