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Cited by 258

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Conservation of the Duchenne Muscular Dystrophy Gene in Mice and Humans

Hoffman, Eric P., Monaco, Anthony P., Feener, Chris C., Kunkel, Louis M.·1987·Science

Abstract

A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.

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Metadata

Authors
Hoffman, E. P., Monaco, A. P., Feener, C. C., & Kunkel, L. M.
Venue
Science
Published
1987-10-16
Volume
238
Issue
4825
Pages
347-350
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1988936141
Cited by
258
References
0
FWCI
11.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Conservation of the Duchenne Muscular Dystrophy Gene in Mice and Humans. https://app.cochat.ai/papers/10.1126/science.3659917
The paper
Hoffman, E. P., Monaco, A. P., Feener, C. C., & Kunkel, L. M. (1987). Conservation of the Duchenne Muscular Dystrophy Gene in Mice and Humans. Science. https://doi.org/10.1126/science.3659917

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.