The DOI matches its Crossref record.
Conservation of the Duchenne Muscular Dystrophy Gene in Mice and Humans
Abstract
A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.
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Citations
Cited by
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Self-citationKoenig, M., Hoffman, E. P., Bertelson, C. J., Monaco, A. P., Feener, C., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90504-6 · Cited by 2,411
Self-citationMyogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,644
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein
Koenig, M., Monaco, A. P., & Kunkel, L. M. (1988) · Cell · doi:10.1016/0092-8674(88)90383-2 · Cited by 1,538
Self-citationThe Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation
Sicinski, P., Geng, Y., Ryder-Cook, A. S., Barnard, E. A., Darlison, M. G., & Barnard, P. J. (1989) · Science · doi:10.1126/science.2662404 · Cited by 1,276
Metadata
- Authors
- Hoffman, E. P., Monaco, A. P., Feener, C. C., & Kunkel, L. M.
- Venue
- Science
- Published
- 1987-10-16
- Volume
- 238
- Issue
- 4825
- Pages
- 347-350
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988936141
- Cited by
- 258
- References
- 0
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hoffman, E. P., Monaco, A. P., Feener, C. C., & Kunkel, L. M. (1987). Conservation of the Duchenne Muscular Dystrophy Gene in Mice and Humans. Science. https://doi.org/10.1126/science.3659917
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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