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Amplification of an Esterase Gene Is Responsible for Insecticide Resistance in a California Culex Mosquito
Abstract
An esterase gene from the mosquito Culex quinquefasciatus that is responsible for resistance to a variety of organophosphorus (OP) insecticides was cloned in λgt11 phage. This gene was used to investigate the genetic mechanism of the high production of the esterase B1 it encodes in OP-resistant Culex quinquefasciatus Say (Tem-R strain) from California. Adults of the Tem-R strain were found to possess at least 250 times more copies of the gene than adults of a susceptible strain (S-Lab). The finding that selection by pesticides may result in the amplification of genes encoding detoxifying enzymes in whole, normally developed, reproducing insects emphasizes the biological importance of this mechanism and opens new areas of investigation in pesticide resistance management.
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Citations
Cited by
Insecticide Resistance in Insect Vectors of Human Disease
Hemingway, J., & Ranson, H. (2000) · Annual Review of Entomology · doi:10.1146/annurev.ento.45.1.371 · Cited by 1,558
The evolutionary origins of pesticide resistance
Hawkins, N. J., Bass, C., Dixon, A., & Neve, P. (2019) · Biological Reviews · doi:10.1111/brv.12440 · Cited by 836
Antifreeze Proteins of Teleost Fishes
Fletcher, G. L., Hew, C. L., & Davies, P. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.359 · Cited by 508
The molecular basis of two contrasting metabolic mechanisms of insecticide resistance
Hemingway, J. (2000) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00079-5 · Cited by 345
Coping with Thermal Challenges: Physiological Adaptations to Environmental Temperatures
Tattersall, G. J., Sinclair, B. J., Withers, P. C., Fields, P. A., Seebacher, F., Cooper, C. E., & Maloney, S. K. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110055 · Cited by 340
Metadata
- Authors
- Mouchès, C., Pasteur, N., Bergé, J. B., Hyrien, O., Raymond, M., Robert de Saint Vincent, B., de Silvestri, M., & Georghiou, G. P.
- Venue
- Science
- Published
- 1986-08-15
- Volume
- 233
- Issue
- 4765
- Pages
- 778-780
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2087662072
- Cited by
- 345
- References
- 0
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Amplification of an Esterase Gene Is Responsible for Insecticide Resistance in a California Culex Mosquito. https://app.cochat.ai/papers/10.1126/science.3755546
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- Mouchès, C., Pasteur, N., Bergé, J. B., Hyrien, O., Raymond, M., Robert de Saint Vincent, B., de Silvestri, M., & Georghiou, G. P. (1986). Amplification of an Esterase Gene Is Responsible for Insecticide Resistance in a California Culex Mosquito. Science. https://doi.org/10.1126/science.3755546
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
