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Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements
Abstract
The 5′ flanking DNA of the rat insulin I gene contains sequences controlling cell-specific expression. Analysis of this region by replacement of specific portions with nondiscriminatory control elements from viral systems shows that a transcriptional enhancer is located in the distal portion of the 5′ flanking DNA; its position has been mapped by deletion analysis. Additional experiments suggest that another distinct regulatory element is located more proximal to the transcription start site. The activity of both elements is restricted to pancreatic B cells. The combinatorial effect of multiple control elements could explain the cell-specific expression of insulin genes.
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Citations
Cited by
IPF1, a homeodomain-containing transactivator of the insulin gene.
Ohlsson, H., Karlsson, K., & Edlund, T. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06109.x · Cited by 888
Self-citationDisruption of imprinting caused by deletion of the H19 gene region in mice
Leighton, P. A., Ingram, R. S., Eggenschwiler, J., Efstratiadis, A., & Tilghman, S. M. (1995) · Nature · doi:10.1038/375034a0 · Cited by 757
Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., et al. (2000) · Nature Medicine · doi:10.1038/75050 · Cited by 745
Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
Fu, Z., R. Gilbert, E., & Liu, D. (2013) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 732
Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB
Peng, H.-B., Libby, P., & Liao, J. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.14214 · Cited by 710
Metadata
- Authors
- Edlund, T., Walker, M. D., Barr, P. J., & Rutter, W. J.
- Venue
- Science
- Published
- 1985-11-22
- Volume
- 230
- Issue
- 4728
- Pages
- 912-916
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082802847
- Cited by
- 670
- References
- 0
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements. https://app.cochat.ai/papers/10.1126/science.3904002
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- Edlund, T., Walker, M. D., Barr, P. J., & Rutter, W. J. (1985). Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements. Science. https://doi.org/10.1126/science.3904002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
