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Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of Langerhans
Abstract
Three-dimensional reconstructions of islets of Langerhans, based on immunofluorescent staining of successive serial sections with antiserums to insulin, glucagon, somatostatin, and pancreatic polypeptide reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas. The two types of islets are situated in regions of exocrine tissue that are drained by different excretory ducts. This demonstration contradicts the assumption that all islets in the pancreas are similar in their endocrine cell content.
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Cited by
Brissova, M., Fowler, M. J., Nicholson, W. E., Chu, A., Hirshberg, B., Harlan, D. M., & Powers, A. C. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5c6684.2005 · Cited by 797
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea
Yoon, K. H., Ko, S. H., Cho, J. H., Lee, J. M., Ahn, Y. B., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020735 · Cited by 649
Islet β-cell secretion determines glucagon release from neighbouring α-cells
Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P.-L., & Wollheim, C. B. (2003) · Nature Cell Biology · doi:10.1038/ncb951 · Cited by 383
The pancreatic islets in diabetes
Gepts, W., & Lecompte, P. M. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90417-4 · Cited by 349
Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene
Herrera, P.-L., Huarte, J., Sanvito, F., Meda, P., Orci, L., & Vassalli, J.-D. (1991) · Development · doi:10.1242/dev.113.4.1257 · Cited by 269
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Metadata
- Authors
- Baetens, D., Malaisse-Lagae, F., Perrelet, A., & Orci, L.
- Venue
- Science
- Published
- 1979-12-14
- Volume
- 206
- Issue
- 4424
- Pages
- 1323-1325
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073635911
- Cited by
- 237
- References
- 0
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of Langerhans. https://app.cochat.ai/papers/10.1126/science.390711
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- Baetens, D., Malaisse-Lagae, F., Perrelet, A., & Orci, L. (1979). Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of Langerhans. Science. https://doi.org/10.1126/science.390711
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
