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Tissue Plasminogen Activator Reduces Neurological Damage After Cerebral Embolism
Abstract
Intravenous administration of tissue plasminogen activator immediately after the injection of numerous small blood clots into the carotid circulation in rabbit embolic stroke model animals caused a significant reduction in neurological damage. In vitro studies indicate that tissue plasminogen activator produced substantial lysis of clots at concentrations comparable to those expected in vivo, suggesting that this may be the mechanism of action of this drug. Drug-induced hemorrhages were not demonstrable. Tissue plasminogen activator may be of value for the immediate treatment of embolic stroke.
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Citations
Cited by
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Higashida, R. T., & Furlan, A. J. (2003) · Stroke · doi:10.1161/01.str.0000082721.62796.09 · Cited by 1,543
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke · doi:10.1161/strokeaha.108.541128 · Cited by 1,352
Self-citationChamorro, Á., Dirnagl, U., Urra, X., & Planas, A. M. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00114-9 · Cited by 1,198
Ischemic stroke: experimental models and reality
Sommer, C. J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1667-0 · Cited by 599
Metadata
- Authors
- Zivin, J. A., Fisher, M., DeGirolami, U., Hemenway, C. C., & Stashak, J. A.
- Venue
- Science
- Published
- 1985-12-13
- Volume
- 230
- Issue
- 4731
- Pages
- 1289-1292
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083268271
- Cited by
- 380
- References
- 0
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tissue Plasminogen Activator Reduces Neurological Damage After Cerebral Embolism. https://app.cochat.ai/papers/10.1126/science.3934754
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- Zivin, J. A., Fisher, M., DeGirolami, U., Hemenway, C. C., & Stashak, J. A. (1985). Tissue Plasminogen Activator Reduces Neurological Damage After Cerebral Embolism. Science. https://doi.org/10.1126/science.3934754
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
