All Members of the MHC Multigene Family Respond to Thyroid Hormone in a Highly Tissue-Specific Manner
Abstract
In mammals different isoforms of myosin heavy chain are encoded by the members of a multigene family. The expression of each gene of this family is regulated in a tissue- and developmental stage-specific manner as well as by hormonal and various pathological stimuli. In this study the molecular basis of isoform switches induced in myosin heavy chain by thyroid hormone was investigated. The expression of the myosin heavy chain gene family was analyzed in seven different muscles of adult rats subjected to hypo- or hyperthyroidism with complementary DNA probes specific for six different myosin heavy chain genes. The results demonstrate that all six genes are responsive to thyroid hormone. More interestingly, the same myosin heavy chain gene can be regulated by thyroid hormone in highly different modes, even in opposite directions, depending on the tissue in which it is expressed. Furthermore, the skeletal embryonic and neonatal myosin heavy chain genes, so far considered specific to these two developmental stages, can be reinduced by hypothyroidism in specific adult muscles.
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Thyroid hormone (T3) can regulate MyHC gene expression.
“Thyroid hormone (T3) can regulate MyHC gene expression (42).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [42]
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References 38 · Cited by 621
- Authors
- Izumo, S., Nadal-Ginard, B., & Mahdavi, V.
- Affiliations
- Boston Children's Hospital (US)
- Laboratory of Molecular and Cellular Cardiology, Department of Cardiology, Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
- Venue
- Science
- Published
- 1986-02-07
- Volume
- 231
- Issue
- 4738
- Pages
- 597-600
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023089345
- Cited by
- 621
- References
- 38
- Citations by year
- 2024: 4 · 2023: 1 · 2022: 3 · 2021: 7 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 11 · 2012: 4
- FWCI
- 16.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- myosin heavy chain, thyroid hormones, isoform switching, hypothyroidism, hyperthyroidism, tissue-specific gene regulation, skeletal muscle, embryonic myosin heavy chain, neonatal myosin heavy chain, gene expression regulation
- MeSH terms
- Animals, Diaphragm, Genes, Heart, Hyperthyroidism, Hypothyroidism, Male, Muscles, Myocardium, Myosins, Thyroid Hormones, Muscle Development, Rats
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