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Diabetic Cataracts and Flavonoids
Abstract
Oral administration of quercitrin, an inhibitor of aldose reductase, leads to a significant decrease in the accumulation of sorbitol in the lens of diabetic Octodon degus . The onset of cataract is effectively delayed when quercitrin is continuously administered. Thus in these diabetic animals, as in galactosemic rats, the use of an effective aldose reductase inhibitor impedes the course of cataract development. These observations support the hypothesis that in diabetes, as in galactosemia, aldose reductase plays a key role in initiating the formation of lens opacity.
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Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
The biochemistry and medical significance of the flavonoids
Havsteen, B. H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,672
Flavonoids, a class of natural products of high pharmacological potency
Havsteen, B. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90262-9 · Cited by 1,615
RETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D'Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 721
RetractedRecent Research on the Health Benefits of Blueberries and Their Anthocyanins
Kalt, W., Cassidy, A., Howard, L. R., Krikorian, R., Stull, A. J., Tremblay, F., & Zamora-Ros, R. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz065 · Cited by 659
Metadata
- Authors
- Varma, S. D., Mizuno, A., & Kinoshita, J. H.
- Venue
- Science
- Published
- 1977-01-14
- Volume
- 195
- Issue
- 4274
- Pages
- 205-206
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039115551
- Cited by
- 189
- References
- 0
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Varma, S. D., Mizuno, A., & Kinoshita, J. H. (1977). Diabetic Cataracts and Flavonoids. Science. https://doi.org/10.1126/science.401544
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