Menopausal flushes: a neuroendocrine link with pulsatile luteinizing hormone secretion
Abstract
Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.
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Blood sampling at frequent intervals has revealed synchronization of LH pulses and hot flushes.
“Blood sampling at frequent intervals have revealed synchronization of LH pulses and hot flushes (Casper et al., 1979; Tataryn et al., 1979).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Casper et al., 1979
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References 24 · Cited by 267
- Authors
- Casper, R. F., Yen, S. S. C., & Wilkes, M. M.
- Affiliations
- University of California San Diego (US)
- ORCID
- Casper, R. F.
- Venue
- Science
- Published
- 1979-08-24
- Volume
- 205
- Issue
- 4408
- Pages
- 823-825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979122053
- Cited by
- 267
- References
- 24
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- luteinizing hormone secretion, pulsatile hormone secretion, gonadotropin-releasing hormone, pituitary gland, catecholamines, prolactin, menopause
- MeSH terms
- Climacteric, Dopamine, Epinephrine, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Middle Aged, Norepinephrine, Prolactin
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