The DOI matches its Crossref record.
Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle
Abstract
Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in adipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg 2+ ), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.
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Citations
Cited by
Relation between mitochondrial calcium transport and control of energy metabolism
Hansford, R. G. (1985) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0034084 · Cited by 370
Role of calcium in the hormonal regulation of liver metabolism
Williamson, J. R., Cooper, R. H., & Hoek, J. B. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(81)90012-4 · Cited by 317
Inositol and human reproduction. From cellular metabolism to clinical use
Milewska, E. M., Czyzyk, A., Meczekalski, B., & Genazzani, A. D. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1188282 · Cited by 69
Metadata
- Authors
- Jarett, L., & Seals, J. R.
- Venue
- Science
- Published
- 1979-12-21
- Volume
- 206
- Issue
- 4425
- Pages
- 1407-1408
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012282437
- Cited by
- 224
- References
- 0
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle. https://app.cochat.ai/papers/10.1126/science.505013
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- Jarett, L., & Seals, J. R. (1979). Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle. Science. https://doi.org/10.1126/science.505013
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
