Induction of Mitosis in Mature Neurons in Central Nervous System by Sustained Depolarization
Abstract
DNA synthesis and mitosis have been induced in vitro in fully differentiated neurons from the central nervous system by depolarization with a variety of agents that produce a sustained rise in the intracellular sodium ion concentration and a decrease in the potassium ion concentration. Depolarization was followed in less than 1 hour by an increase in RNA synthesis and in 3 hours by initiation of DNA synthesis. Apparently normal nuclear mitosis ensued, but cytokinesis was not completed in most cells; this resulted in the formation of binucleate neurons. The daughter nuclei each contained the same amount of DNA as the diploid preinduction parental neurons; this implies that true mitogenic replication was induced.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Quiescent (G0) mature chick spinal cord neurons showed mitotic activity after depolarization.
“Secondly, quiescent (G0) mature chick spinal cord neurons showed mitotic activity after depolarization (Cone and Cone, 1976) (Figure 2).”
From Membrane potential and cancer progression (2013) · cites this paper as Cone and Cone, 1976
Cited by
Sorted by citations
Membrane potential and cancer progression
Yang, M., & Brackenbury, W. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00185 · Cited by 614 · see citing works
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle
Blackiston, D. J., McLaughlin, K. A., & Levin, M. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9888 · Cited by 468 · see citing works
Lobikin, M., Chernet, B., Lobo, D., & Levin, M. (2012) · Physical Biology · doi:10.1088/1478-3975/9/6/065002 · Cited by 166 · see citing works
- Authors
- Cone, C. D., & Cone, C. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Science
- Published
- 1976-04-09
- Volume
- 192
- Issue
- 4235
- Pages
- 155-158
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984349011
- Cited by
- 208
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 3 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 2 · 2012: 7
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- mature neurons, sustained depolarization, sodium ion concentration, potassium concentration, DNA synthesis, RNA synthesis, cytokinesis, central nervous system neurons
- MeSH terms
- Animals, Cell Division, Cells, Cultured, Chick Embryo, Gramicidin, Membrane Potentials, Mitosis, Neurons, Ouabain, RNA, Sodium Chloride, Veratridine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
