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Phase Variation of Type 1 Fimbriae in Escherichia coli Is Under Transcriptional Control
Abstract
An operon fusion of the lac genes to those required for synthesis of type 1 fimbriae (pili) has been achieved in a K12 strain of Escherichia coli lysogenized by the bacteriophage mu d (Ap r , lac ). Synthesis of β-galactosidase, therefore, reflected pil gene transcription and was used as a probe of fimbrial regulation. Expression of the operon fusion was found to oscillate, demonstrating that phase variation between fimbriate and nonfimbriate states is under transcriptional control. The transition rates from fimbriate to nonfimbriate were 1.05 × 10 -3 per bacterium per generation and from nonfimbriate to fimbriate, 3.12 × 10 -3 per bacterium per generation.
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Cited by
Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains
Gaastra, W., & de Graaf, F. K. (1982) · Microbiological Reviews · doi:10.1128/mmbr.46.2.129-161.1982 · Cited by 527
An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli.
Abraham, J. M., Freitag, C. S., Clements, J. R., & Eisenstein, B. I. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5724 · Cited by 481
Self-citationDuplication and amplification of toxin genes in Vibrio cholerae
Mekalanos, J. J. (1983) · Cell · doi:10.1016/0092-8674(83)90228-3 · Cited by 393
Phase-variable outer membrane proteins in Escherichia coli
Owen, P., Meehan, M., de Loughry-Doherty, H., & Henderson, I. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00124.x · Cited by 88
Aslanzadeh, J., & Paulissen, L. J. (1992) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1992.tb02034.x · Cited by 35
Metadata
- Authors
- Eisenstein, B. I.
- Venue
- Science
- Published
- 1981-10-16
- Volume
- 214
- Issue
- 4518
- Pages
- 337-339
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030650670
- Cited by
- 268
- References
- 0
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- closed
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