The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca 2+ -Dependent Protein Kinase
Abstract
Arachidonate and other unsaturated long-chain fatty acids were found to activate protein kinase C from human neutrophils. Kinase activation by arachidonate required calcium and was enhanced by diolein but did not require exogenous phosphatidylserine. Submaximal levels of arachidonate also enhanced the affinity of the kinase for calcium during activation by phosphatidylserine. Thus the release of arachidonate, which is triggered in many cell types by ligand-receptor interactions, could play a second messenger role in the regulation of cellular function by activation of protein kinase C.
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Cites
Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., & Nishizuka, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34459-4 · Cited by 4,725
Cited by
Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083
The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function
Rossi, F. (1986) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(86)90005-4 · Cited by 658
Guthrie, L. A., McPhail, L. C., Henson, P. M., & Johnston, R. B. (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.6.1656 · Cited by 616
Self-citationEssential Fatty Acids and the Brain
Haag, M. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800308 · Cited by 421
Clark, R. A., Leidal, K. G., Pearson, D. W., & Nauseef, W. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61312-2 · Cited by 271
Metadata
- Authors
- McPhail, L. C., Clayton, C. C., & Snyderman, R.
- Venue
- Science
- Published
- 1984-05-11
- Volume
- 224
- Issue
- 4649
- Pages
- 622-625
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083611460
- Cited by
- 614
- References
- 1
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- McPhail, L. C., Clayton, C. C., & Snyderman, R. (1984). A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca 2+ -Dependent Protein Kinase. Science. https://doi.org/10.1126/science.6231726
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
