The DOI matches its Crossref record.
Constitutive Fragile Sites and Cancer
Abstract
Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.
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Citations
Cited by
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C. L., & de Lange, T. (2009) · Cell · doi:10.1016/j.cell.2009.06.021 · Cited by 990
Ohta, M., Inoue, H., Cotticelli, M. G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P., Druck, T., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81034-x · Cited by 990
Secondary Acute Myeloid Leukemia in Children Treated for Acute Lymphoid Leukemia
Pui, C.-H., Behm, F. G., Raimondi, S. C., Dodge, R. K., George, S. L., Rivera, G. K., Mirro, J., Kalwinsky, D. K., Dahl, G. V., Murphy, S. B., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210302 · Cited by 441
Coquelle, A., Pipiras, E., Toledo, F., Buttin, G., & Debatisse, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80201-9 · Cited by 391
Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation
Peng, J. C., & Karpen, G. H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000435 · Cited by 183
Metadata
- Authors
- Yunis, J. J., & Soreng, A. L.
- Venue
- Science
- Published
- 1984-12-07
- Volume
- 226
- Issue
- 4679
- Pages
- 1199-1204
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038108954
- Cited by
- 680
- References
- 0
- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Constitutive Fragile Sites and Cancer. https://app.cochat.ai/papers/10.1126/science.6239375
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- Yunis, J. J., & Soreng, A. L. (1984). Constitutive Fragile Sites and Cancer. Science. https://doi.org/10.1126/science.6239375
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
