Neural Gonadal Steroid Actions
Abstract
Neurons sensitive to gonadal steroids are located strategically within neural circuits that mediate behaviors broadly related to the reproductive process. Some neuronal events and properties are regulated by these hormones. Variability in the occurrence and distribution of particular neural hormonal sensitivities across species may be related to variations in the hormonal requirements for sexual differentiation and for activation of reproductive behaviors.
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Inhibition of aromatase activity by pharmacologic antagonists feminizes sexual behavior of male rats.
“Inhibition of aromatase activity by pharmacologic antagonists feminizes sexual behavior of male rats (Gladue and Clemens 1980; McEwen 1981).”
From Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat. (2002) · cites this paper as McEwen 1981
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References 108 · Cited by 438
- Authors
- McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- McEwen, Bruce S.
- ORCID
- McEwen, Bruce S.
- Venue
- Science
- Published
- 1981-03-20
- Volume
- 211
- Issue
- 4488
- Pages
- 1303-1311
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048950217
- Cited by
- 438
- References
- 108
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 1 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 10 · 2013: 2 · 2012: 6
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- sex steroids, reproductive behavior, sexual differentiation, neural circuits, interspecific variation, neuroendocrine regulation of reproduction
- MeSH terms
- Androgens, Animals, Brain, Estrogens, Female, Gonads, Humans, Male, Neurons, Progestins, Receptors, Cell Surface, Receptors, Progesterone, Sexual Behavior, Sex Differentiation, Gonadal Steroid Hormones, Species Specificity, Vertebrates, Rats
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