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Phagocyte Impotence Caused by an Invasive Bacterial Adenylate Cyclase
Abstract
For unknown reasons, humans infected with the bacterium Bordetella pertussis are exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble, heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic cells and catalyzes the unregulated formation of adenosine 3′,5′-monophosphate (cyclic AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain Bordetella -induced aphylaxis and may prove to be useful for investigating a variety of cyclic AMP-governed processes.
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Cited by
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Linhartová, I., Bumba, L., Mašín, J., Basler, M., Osička, R., Kamanová, J., Procházková, K., Adkins, I., Hejnová-Holubová, J., Sadílková, L., et al. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00231.x · Cited by 530
Guermonprez, P., Khelef, N., Blouin, E., Rieu, P., Ricciardi-Castagnoli, P., Guiso, N., Ladant, D., & Leclerc, C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1035 · Cited by 339
Ahmad, J. N., Holubova, J., Benada, O., Kofronova, O., Stehlik, L., Vasakova, M., & Sebo, P. (2019) · mBio · doi:10.1128/mbio.01743-19 · Cited by 38
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Goldsmith, J. A., DiVenere, A. M., Maynard, J. A., & McLellan, J. S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111196 · Cited by 28
Metadata
- Authors
- Confer, D. L., & Eaton, J. W.
- Venue
- Science
- Published
- 1982-09-03
- Volume
- 217
- Issue
- 4563
- Pages
- 948-950
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049338606
- Cited by
- 440
- References
- 0
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Confer, D. L., & Eaton, J. W. (1982). Phagocyte Impotence Caused by an Invasive Bacterial Adenylate Cyclase. Science. https://doi.org/10.1126/science.6287574
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