The DOI matches its Crossref record.
Ivermectin: A Potent New Antiparasitic Agent
Abstract
Ivermectin is the 22,23-dihydro derivative of avermectin B 1 , a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis . It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by γ-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine.
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Citations
Cited by
Lumaret, J.-P., Errouissi, F., Floate, K., Rombke, J., & Wardhaugh, K. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800399257 · Cited by 367
Jex, A. R., Liu, S., Li, B., Young, N. D., Hall, R. S., Li, Y., Yang, L., Zeng, N., Xu, X., Xiong, Z., et al. (2011) · Nature · doi:10.1038/nature10553 · Cited by 276
The life and times of ivermectin — a success story
Õmura, S., & Crump, A. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1048 · Cited by 273
Ivermectin for preventing and treating COVID-19
Popp, M., Reis, S., Schießer, S., Hausinger, R. I., Stegemann, M., Metzendorf, M.-I., Kranke, P., Meybohm, P., Skoetz, N., & Weibel, S. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015017.pub3 · Cited by 169
Gill, J. H., Redwin, J. M., Van Wyk, J. A., & Lacey, E. (1995) · International Journal for Parasitology · doi:10.1016/0020-7519(94)00087-5 · Cited by 150
Metadata
- Authors
- Campbell, W. C., Fisher, M. H., Stapley, E. O., Albers-Schönberg, G., & Jacob, T. A.
- Venue
- Science
- Published
- 1983-08-26
- Volume
- 221
- Issue
- 4613
- Pages
- 823-828
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006810880
- Cited by
- 825
- References
- 0
- FWCI
- 20.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Campbell, W. C., Fisher, M. H., Stapley, E. O., Albers-Schönberg, G., & Jacob, T. A. (1983). Ivermectin: A Potent New Antiparasitic Agent. Science. https://doi.org/10.1126/science.6308762
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
