The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Splice Junctions: Association with Variation in Protein Structure
Abstract
A comparison between eukaryotic gene sequences and protein sequences of homologous enzymes from bacterial and mammalian organisms shows that intron-exon junctions frequently coincide with variable surface loops of the protein structures. The altered surface structures can account for functional differences among the members of a family. Sliding of the intron-exon junctions may constitute one mechanism for generating length polymorphisms and divergent sequences found in protein families. Since intron-exon junctions map to protein surfaces, the alterations mediated by sliding of these junctions can be effected without disrupting the stability of the protein core.
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Cites
Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
Cited by
Ny, T., Elgh, F., & Lund, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5355 · Cited by 299
Metadata
- Authors
- Craik, C. S., Rutter, W. J., & Fletterick, R.
- Venue
- Science
- Published
- 1983-06-10
- Volume
- 220
- Issue
- 4602
- Pages
- 1125-1129
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023881865
- Cited by
- 259
- References
- 1
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Craik, C. S., Rutter, W. J., & Fletterick, R. (1983). Splice Junctions: Association with Variation in Protein Structure. Science. https://doi.org/10.1126/science.6344214
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
