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Coronary Artery Spasm Induced in Atherosclerotic Miniature Swine
Abstract
Angiographically demonstrable coronary artery spasm could be provoked repeatedly by giving intracoronary or intravenous injections of histamine to miniature swine with experimentally induced atherosclerotic lesions of the coronary artery. The spasm induced in this way subsided either spontaneously or after the administration of nitroglycerin and was prevented by a calcium antagonist or an agent that blocks histamine H 1 receptors. This model, which suggests that atherosclerotic changes may be one of the primary factors in the occurrence of coronary artery spasm, should facilitate studies on the pathogenesis of this condition.
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Citations
Cited by
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Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114688 · Cited by 1,017
Barger, A. C., Beeuwkes, R., Lainey, L. L., & Silverman, K. J. (1984) · New England Journal of Medicine · doi:10.1056/nejm198401193100307 · Cited by 849
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Schwartz, S. M., Campbell, G. R., & Campbell, J. H. (1986) · Circulation Research · doi:10.1161/01.res.58.4.427 · Cited by 759
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MONCADA, S., & HIGGS, E. A. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01383.x · Cited by 759
Endothelium-derived relaxing factor and coronary vasospasm.
Vanhoutte, P. M., & Shimokawa, H. (1989) · Circulation · doi:10.1161/01.cir.80.1.1 · Cited by 416
Self-citation
Metadata
- Authors
- Shimokawa, H., Tomoike, H., Nabeyama, S., Yamamoto, H., Araki, H., Nakamura, M., Ishii, Y., & Tanaka, K.
- Venue
- Science
- Published
- 1983-08-05
- Volume
- 221
- Issue
- 4610
- Pages
- 560-562
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013545198
- Cited by
- 369
- References
- 0
- FWCI
- 21.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Coronary Artery Spasm Induced in Atherosclerotic Miniature Swine. https://app.cochat.ai/papers/10.1126/science.6408736
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- Shimokawa, H., Tomoike, H., Nabeyama, S., Yamamoto, H., Araki, H., Nakamura, M., Ishii, Y., & Tanaka, K. (1983). Coronary Artery Spasm Induced in Atherosclerotic Miniature Swine. Science. https://doi.org/10.1126/science.6408736
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.