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1,25-Dihydroxyvitamin D 3 : a Novel Immunoregulatory Hormone
Abstract
The hormonal form of vitamin D 3 , 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], at picomolar concentrations, inhibited the growth-promoting lymphokine interleukin-2, which is produced by human T lymphocytes activated in vitro by the mitogen phytohemagglutinin. Other metabolites of vitamin D 3 were less effective than 1,25(OH) 2 D 3 in suppressing interleukin-2; their order of potency corresponded to their respective affinity for the 1,25(OH) 2 D 3 receptor, suggesting that the effect on interleukin-2 was mediated by this specific receptor. The proliferation of mitogen-activated lymphocytes was also inhibited by 1,25(OH) 2 D 3 . This effect of the hormone became more pronounced at later stages of the culture. These findings demonstrate that 1,25(OH) 2 D 3 is an immunoregulatory hormone.
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Citations
Cited by
Holick, M. F. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1678s · Cited by 2,762
A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection
Gombart, A. F., Pierre, A., & Maggini, S. (2020) · Nutrients · doi:10.3390/nu12010236 · Cited by 1,358
Boonstra, A., Barrat, F. J., Crain, C., Heath, V. L., Savelkoul, H. F. J., & O’Garra, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4974 · Cited by 1,123
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System
Veldman, C. M., Cantorna, M. T., & DeLuca, H. F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1605 · Cited by 710
Metadata
- Authors
- Tsoukas, C. D., Provvedini, D. M., & Manolagas, S. C.
- Venue
- Science
- Published
- 1984-06-29
- Volume
- 224
- Issue
- 4656
- Pages
- 1438-1440
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966237185
- Cited by
- 526
- References
- 0
- FWCI
- 19.69
- Type
- journal article
- Language
- en
- Open access
- closed
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