The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Potentiation of Opiate Analgesia and Apparent Reversal of Morphine Tolerance by Proglumide
Abstract
Exogenous cholecystokinin selectively antagonizes opiate analgesia, which suggests that endogenous cholecystokinin may act physiologically as an opiate antagonist and may play a role in opiate tolerance. The use of the selective cholecystokinin antagonist proglumide provided a test of these hypotheses in rats that were either inexperienced with or tolerant to opiates. Proglumide potentiated analgesia produced by morphine and endogenous opiates and seemed to reverse tolerance. These results suggest that endogenous cholecystokinin systems oppose the action of opiates.
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Citations
Cites
Organization of endogenous opiate and nonopiate pain control systems
Watkins, L. R., & Mayer, D. J. (1982) · Science · doi:10.1126/science.6281891 · Cited by 791
Self-citation
Cited by
The neuroscience of placebo effects: connecting context, learning and health
Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J., & Christie, M. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005942 · Cited by 802
Watkins, L. R., Hutchinson, M. R., Rice, K. C., & Maier, S. F. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.08.002 · Cited by 438
Self-citationThe Pain of Being Sick: Implications of Immune-to-Brain Communication for Understanding Pain
Watkins, L. R., & Maier, S. F. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.29 · Cited by 388
Self-citationOpioid-induced hyperalgesia: abnormal or normal pain?
Simonnet, G., & Rivat, C. (2003) · NeuroReport · doi:10.1097/00001756-200301200-00001 · Cited by 273
Metadata
- Authors
- Watkins, L. R., Kinscheck, I., & Mayer, D. J.
- Venue
- Science
- Published
- 1984-04-27
- Volume
- 224
- Issue
- 4647
- Pages
- 395-396
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967565278
- Cited by
- 259
- References
- 1
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
