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Cat Scratch Disease: A Bacterial Infection
Abstract
Histopathologic examination of lymph nodes from 39 patients with clinical and pathological criteria for cat scratch disease revealed delicate pleomorphic Gram-negative bacilli in 34 of the 39 nodes. They were within the walls of capillaries in or near areas of follicular hyperplasia and within microabscesses. They were best seen with the Warthin-Starry silver impregnation stain. Organisms in lymph node sections exposed to convalescent serum from three patients and to immunoperoxidase stained equally well with all three samples. The organisms did not react with hyperimmune sera to Legionella pneumophila nor to several species of Rickettsia. These bacilli appear to be the causative agents of cat scratch disease.
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Cited by
The Agent of Bacillary Angiomatosis: An Approach to the Identification of Uncultured Pathogens
Relman, D. A., Loutit, J. S., Schmidt, T. M., Falkow, S., & Tompkins, L. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012063232301 · Cited by 901
Isolation of Rochalimaea Species from Cutaneous and Osseous Lesions of Bacillary Angiomatosis
Koehler, J. E., Quinn, F. D., Berger, T. G., LeBoit, P. E., & Tappero, J. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212033272303 · Cited by 459
Asano, S. (2012) · Journal of Clinical and Experimental Hematopathology · doi:10.3960/jslrt.52.1 · Cited by 169
Cat Scratch Disease and Other Bartonella Infections
Zangwill, K. M. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-4726-9_13 · Cited by 48
Metadata
- Authors
- Wear, D. J., Margileth, A. M., Hadfield, T. L., Fischer, G. W., Schlagel, C. J., & King, F. M.
- Venue
- Science
- Published
- 1983-09-30
- Volume
- 221
- Issue
- 4618
- Pages
- 1403-1405
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078802220
- Cited by
- 347
- References
- 0
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cat Scratch Disease: A Bacterial Infection. https://app.cochat.ai/papers/10.1126/science.6612349
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- Wear, D. J., Margileth, A. M., Hadfield, T. L., Fischer, G. W., Schlagel, C. J., & King, F. M. (1983). Cat Scratch Disease: A Bacterial Infection. Science. https://doi.org/10.1126/science.6612349
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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