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Specific Endocrine Tissue Marker Defined by a Monoclonal Antibody
Abstract
One of two mouse monoclonal antibodies (LK2H10) produced by hybridoma technology against a human endocrine tumor (pheochromocytoma) demonstrated specific immunoreactivity for 69 normal and neoplastic endocrine cells and tissues known to contain secretory granules. This immunoreactivity was specific, since other normal tissues, tumors from endocrine cells without granules, and tumors from other nonendocrine tissues were negative when tested with antibody LK2H10. The antibody reacted with human fetal adrenal medulla and human pancreatic endocrine cells and with adrenal medullary cells from monkeys and pigs. The antigen detected by antibody LK2H10 is associated with cytoplasmic secretory granules, has an estimated molecular weight of 68,000, and may be related to human chromogranin.
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Citations
Cited by
The diagnosis and medical management of advanced neuroendocrine tumors.
Kaltsas, G. A., Besser, G. M., & Grossman, A. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0014 · Cited by 674
The chromogranins A and B: The first 25 years and future perspectives
Winkler, H., & Fischer-Colbrie, R. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90222-n · Cited by 655
Secretion of Chromogranin A by Peptide-Producing Endocrine Neoplasms
O'Connor, D. T., & Deftos, L. J. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605013141803 · Cited by 477
Prognostic factors of long-term outcome in gastroenteropancreatic neuroendocrine tumours
Pape, U.-F., Berndt, U., Muller-Nordhorn, J., Bohmig, M., Roll, S., Koch, M., Willich, S. N., & Wiedenmann, B. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0017 · Cited by 384
Chromogranin A: its clinical value as marker of neuroendocrine tumours.
Nobels, Kwekkeboom, Bouillon, & Lamberts (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00305.x · Cited by 151
Metadata
- Authors
- Lloyd, R. V., & Wilson, B. S.
- Venue
- Science
- Published
- 1983-11-11
- Volume
- 222
- Issue
- 4624
- Pages
- 628-630
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971020206
- Cited by
- 337
- References
- 0
- FWCI
- 17.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
