The DOI matches its Crossref record.
Radioactive Labeling of Antibody: A Simple and Efficient Method
Abstract
A simple and efficient method of covalently coupling the strong chelator diethylenetriaminepentaacetic acid to proteins was developed for radiolabeling immunoglobulin G antibodies. After being coupled and labeled with indium-111, a monoclonal antibody to carcinoembryonic antigen retained its ability to bind to its antigen in vitro and in vivo. In nude mice with a human colorectal xenograft, 41 percent of the injected radioactivity became localized in each gram of xenograft at 24 hours compared with 9 percent for control antibody and 19 percent for radioiodinated antibody to carcinoembryonic antigen.
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Citations
Cited by
Villaraza, A. J. L., Bumb, A., & Brechbiel, M. W. (2010) · Chemical Reviews · doi:10.1021/cr900232t · Cited by 632
Radiometal-Labeled Agents (Non-Technetium) for Diagnostic Imaging
Anderson, C. J., & Welch, M. J. (1999) · Chemical Reviews · doi:10.1021/cr980451q · Cited by 455
Copper radionuclides and radiopharmaceuticals in nuclear medicine
Blower, P. J., Lewis, J. S., & Zweit, J. (1996) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(96)00130-8 · Cited by 406
Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics
Boswell, C. A., Tesar, D. B., Mukhyala, K., Theil, F.-P., Fielder, P. J., & Khawli, L. A. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100261d · Cited by 398
Metadata
- Authors
- Hnatowich, D. J., Layne, W. W., Childs, R. L., Lanteigne, D., Davis, M. A., Griffin, T. W., & Doherty, P. W.
- Venue
- Science
- Published
- 1983-05-06
- Volume
- 220
- Issue
- 4597
- Pages
- 613-615
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026918336
- Cited by
- 408
- References
- 0
- FWCI
- 28.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hnatowich, D. J., Layne, W. W., Childs, R. L., Lanteigne, D., Davis, M. A., Griffin, T. W., & Doherty, P. W. (1983). Radioactive Labeling of Antibody: A Simple and Efficient Method. Science. https://doi.org/10.1126/science.6836304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
