The DOI matches its Crossref record.
Active Shortening Retards the Decline of the Intracellular Calcium Transient in Mammalian Heart Muscle
Abstract
When active shortening of the cat papillary muscle was allowed at any time during a contraction, the intracellular concentration of free calcium ions, detected with the calcium-sensitive bioluminescent protein aequorin, was higher than at comparable times in isometric twitches. The difference was not attributable to the differences of length involved or to motion artifacts, and must have been related to the act of shortening or the difference in force development in the two types of contractions. This observation and the phenomenon of shortening deactivation are both consistent with the hypothesis that attachment of cross bridges increases the affinity of the myofilaments for calcium ions.
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Citations
Cited by
The cellular basis of the length-tension relation in cardiac muscle
ALLEN, D., & KENTISH, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80097-3 · Cited by 589
ter Keurs, H. E. D. J., & Boyden, P. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00011.2006 · Cited by 356
Metadata
- Authors
- Housmans, P. R., Lee, N. K. M., & Blinks, J. R.
- Venue
- Science
- Published
- 1983-07-08
- Volume
- 221
- Issue
- 4606
- Pages
- 159-161
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040622954
- Cited by
- 180
- References
- 0
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Active Shortening Retards the Decline of the Intracellular Calcium Transient in Mammalian Heart Muscle. https://app.cochat.ai/papers/10.1126/science.6857274
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- Housmans, P. R., Lee, N. K. M., & Blinks, J. R. (1983). Active Shortening Retards the Decline of the Intracellular Calcium Transient in Mammalian Heart Muscle. Science. https://doi.org/10.1126/science.6857274
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
