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Direct in Vivo Monitoring of Dopamine Released from Two Striatal Compartments in the Rat
Abstract
Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time scale of seconds. Direct evidence identifying the substance released as dopamine was obtained both voltammetrically and pharmacologically. Administration of α-methyl-p-tyrosine terminates the release of dopamine, although tissue stores of dopamine are still present. Thus there appears to be a compartment for dopamine storage that is not available for immediate release. This compartment appears to be mobilized by amfonelic acid, since administration of this agent after α-methyl-p-tyrosine returns the concentration of dopamine released by electrical stimulation to 75 percent of the original amount.
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Cited by
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Suaud-Chagny, M. F., Chergui, K., Chouvet, G., & Gonon, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90076-e · Cited by 307
Microelectrodes for the Measurement of Catecholamines in Biological Systems
Cahill, P. S., Walker, Q. D., Finnegan, J. M., Mickelson, G. E., Travis, E. R., & Wightman, R. M. (1996) · Analytical Chemistry · doi:10.1021/ac960347d · Cited by 295
Self-citationCocaine Increases Dopamine Release by Mobilization of a Synapsin-Dependent Reserve Pool
Venton, B. J., Seipel, A. T., Phillips, P. E. M., Wetsel, W. C., Gitler, D., Greengard, P., Augustine, G. J., & Wightman, R. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4901-04.2006 · Cited by 246
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Metadata
- Authors
- Ewing, A. G., Bigelow, J. C., & Wightman, R. M.
- Venue
- Science
- Published
- 1983-07-08
- Volume
- 221
- Issue
- 4606
- Pages
- 169-171
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054934912
- Cited by
- 267
- References
- 0
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ewing, A. G., Bigelow, J. C., & Wightman, R. M. (1983). Direct in Vivo Monitoring of Dopamine Released from Two Striatal Compartments in the Rat. Science. https://doi.org/10.1126/science.6857277
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
