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Complete Amino Acid Sequence of Urotensin I, a Hypotensive and Corticotropin-Releasing Neuropeptide from Catostomus
Abstract
Urotensin I, purified from extracts of the urophysis of a teleost fish ( Catostomus commersoni ), exhibits potent hypotensive activity (mammals and birds) and corticotropin-releasing activity (both fish and mammals). The primary structure of this 41-residue peptide was determined to be H-Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2. Extraction with 0.1 N HCl at 100°C cleaves the amino-terminal tripeptide, yielding a fully active analog, urotensin I(4-41). The amino acid sequence was confirmed by measuring the biological activity of synthetic urotensin I(4-41). Urotensin I exhibits a striking sequence homology with ovine corticotropin-releasing factor and with frog sauvagine. These three peptides exhibit similar activities in biological test systems.
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Cited by
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Fisher, L. A., Kikkawa, D. O., Rivier, J. E., Amara, S. G., Evans, R. M., Rosenfeld, M. G., Vale, W. W., & Brown, M. R. (1983) · Nature · doi:10.1038/305534a0 · Cited by 401
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400
Hauger, R. L., Grigoriadis, D. E., Dallman, M. F., Plotsky, P. M., Vale, W. W., & Dautzenberg, F. M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.3 · Cited by 365
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Kormos, V., & Gaszner, B. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.014 · Cited by 329
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Metadata
- Authors
- Lederis, K., Letter, A., McMaster, D., Moore, G., & Schlesinger, D.
- Venue
- Science
- Published
- 1982-10-08
- Volume
- 218
- Issue
- 4568
- Pages
- 162-165
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052530157
- Cited by
- 286
- References
- 0
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Complete Amino Acid Sequence of Urotensin I, a Hypotensive and Corticotropin-Releasing Neuropeptide from Catostomus. https://app.cochat.ai/papers/10.1126/science.6981844
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- Lederis, K., Letter, A., McMaster, D., Moore, G., & Schlesinger, D. (1982). Complete Amino Acid Sequence of Urotensin I, a Hypotensive and Corticotropin-Releasing Neuropeptide from Catostomus. Science. https://doi.org/10.1126/science.6981844
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