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Natural Killer Cells: Their Roles in Defenses Against Disease
Abstract
Natural killer cells are a recently discovered subpopulation of lymphoid cells that are present in most normal individuals of a range of mammalian and avian species. Natural killer cells have spontaneous cytolytic activity against a variety of tumor cells and some normal cells, and their reactivity can be rapidly augmented by interferon. They have characteristics distinct from other types of lymphoid cells and are closely associated with large granular lymphocytes, which comprise about 5 percent of blood or splenic leukocytes. There is increasing evidence that natural killer cells, with the ability to mediate natural resistance against tumors in vivo, certain virus and other microbial diseases, and bone marrow transplants, may play an important role in immune surveillance.
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Citations
Cited by
Health complaints, stress, and distress: Exploring the central role of negative affectivity.
Watson, D., & Pennebaker, J. W. (1989) · Psychological Review · doi:10.1037/0033-295x.96.2.234 · Cited by 3,030
In search of the ‘missing self’: MHC molecules and NK cell recognition
Ljunggren, H.-G., & Kärre, K. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90097-s · Cited by 2,687
NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance
Di Santo, J. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090700 · Cited by 448
Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice
Bix, M., Liao, N.-S., Zijlstra, M., Loring, J., Jaenisch, R., & Raulet, D. (1991) · Nature · doi:10.1038/349329a0 · Cited by 431
The influence of surgical operations on components of the human immune system
Lennard, T. W. J., Shenton, B. K., Borzotta, A., Donnelly, P. K., White, M., Gerrie, L. M., Proud, G., & Taylor, R. M. R. (1985) · Journal of British Surgery · doi:10.1002/bjs.1800721002 · Cited by 406
Metadata
- Authors
- Herberman, R. B., & Ortaldo, J. R.
- Venue
- Science
- Published
- 1981-10-02
- Volume
- 214
- Issue
- 4516
- Pages
- 24-30
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045964137
- Cited by
- 1,336
- References
- 0
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Herberman, R. B., & Ortaldo, J. R. (1981). Natural Killer Cells: Their Roles in Defenses Against Disease. Science. https://doi.org/10.1126/science.7025208
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
