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Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Abstract
Cultured human lymphocytes and rat hepatoma cells were labeled with [ 32 P]orthophosphate and the insulin receptor subunits identified by immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis. In both cell types the 95,000-dalton (β) subunit of the insulin receptor was selectively phosphorylated. Phosphorylation was specifically stimulated by insulin in a dose-dependent fashion after 1 and 15 minutes of hormone treatment, whereas human growth hormone was without effect. This phosphorylation may be a very early event in insulin action.
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Citations
Cited by
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
The role of protein phosphorylation in neural and hormonal control of cellular activity
Cohen, P. (1982) · Nature · doi:10.1038/296613a0 · Cited by 1,123
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives
Thompson, J. A., Grunert, F., & Zimmermann, W. (1991) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860050510 · Cited by 608
Metadata
- Authors
- Kasuga, M., Karlsson, F. A., & Kahn, C. R.
- Venue
- Science
- Published
- 1982-01-08
- Volume
- 215
- Issue
- 4529
- Pages
- 185-187
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965371391
- Cited by
- 1,126
- References
- 0
- FWCI
- 43.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor. https://app.cochat.ai/papers/10.1126/science.7031900
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- Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982). Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor. Science. https://doi.org/10.1126/science.7031900
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
