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Cited by 705

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Atmospheric Reactions of Polycyclic Aromatic Hydrocarbons: Facile Formation of Mutagenic Nitro Derivatives

Pitts, James N., Van Cauwenberghe, Karel A., Grosjean, Daniel, Schmid, Joachim P., Fitz, Dennis R., Belser, William L., Knudson, Gregory B., Hynds, Paul M.·1978·Science

Abstract

Directly active mutagens are formed on exposure of the promutagen benzo[ a ]pyrene to gaseous pollutants in smog. In simulated atmospheres containing 1 part per million nitrogen dioxide and traces of nitric acid, directly mutagenic nitro derivatives are readily formed from both benzo[ a ]pyrene and perylene, a nonmutagen in the Ames reversion assay. Possible formation of direct mutagens by such reactions on sample collection filters, in exhaust effluents, and in the atmosphere should be recognized.

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Metadata

Authors
Pitts, J. N., Van Cauwenberghe, K. A., Grosjean, D., Schmid, J. P., Fitz, D. R., Belser, W. L., Knudson, G. B., & Hynds, P. M.
Venue
Science
Published
1978-11-03
Volume
202
Issue
4367
Pages
515-519
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2065342803
Cited by
705
References
0
FWCI
24.44
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Atmospheric Reactions of Polycyclic Aromatic Hydrocarbons: Facile Formation of Mutagenic Nitro Derivatives. https://app.cochat.ai/papers/10.1126/science.705341
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Pitts, J. N., Van Cauwenberghe, K. A., Grosjean, D., Schmid, J. P., Fitz, D. R., Belser, W. L., Knudson, G. B., & Hynds, P. M. (1978). Atmospheric Reactions of Polycyclic Aromatic Hydrocarbons: Facile Formation of Mutagenic Nitro Derivatives. Science. https://doi.org/10.1126/science.705341

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.