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Atmospheric Reactions of Polycyclic Aromatic Hydrocarbons: Facile Formation of Mutagenic Nitro Derivatives
Abstract
Directly active mutagens are formed on exposure of the promutagen benzo[ a ]pyrene to gaseous pollutants in smog. In simulated atmospheres containing 1 part per million nitrogen dioxide and traces of nitric acid, directly mutagenic nitro derivatives are readily formed from both benzo[ a ]pyrene and perylene, a nonmutagen in the Ames reversion assay. Possible formation of direct mutagens by such reactions on sample collection filters, in exhaust effluents, and in the atmosphere should be recognized.
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Cited by
Tropospheric Air Pollution: Ozone, Airborne Toxics, Polycyclic Aromatic Hydrocarbons, and Particles
Finlayson-Pitts, B. J., & Pitts, J. N. (1997) · Science · doi:10.1126/science.276.5315.1045 · Cited by 1,201
Self-citationA review of atmospheric polycyclic aromatic hydrocarbons: Sources, fate and behavior
Baek, S. O., Field, R. A., Goldstone, M. E., Kirk, P. W., Lester, J. N., & Perry, R. (1991) · Water, Air, and Soil Pollution · doi:10.1007/bf00282628 · Cited by 910
Keyte, I. J., Harrison, R. M., & Lammel, G. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60147a · Cited by 758
Sampling of vehicle emissions for chemical analysis and biological testing.
Schuetzle, D. (1983) · Environmental Health Perspectives · doi:10.1289/ehp.834765 · Cited by 490
Mutagenicity of Nitroaromatic Compounds
Purohit, V., & Basu, A. K. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000002x · Cited by 450
Metadata
- Authors
- Pitts, J. N., Van Cauwenberghe, K. A., Grosjean, D., Schmid, J. P., Fitz, D. R., Belser, W. L., Knudson, G. B., & Hynds, P. M.
- Venue
- Science
- Published
- 1978-11-03
- Volume
- 202
- Issue
- 4367
- Pages
- 515-519
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065342803
- Cited by
- 705
- References
- 0
- FWCI
- 24.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pitts, J. N., Van Cauwenberghe, K. A., Grosjean, D., Schmid, J. P., Fitz, D. R., Belser, W. L., Knudson, G. B., & Hynds, P. M. (1978). Atmospheric Reactions of Polycyclic Aromatic Hydrocarbons: Facile Formation of Mutagenic Nitro Derivatives. Science. https://doi.org/10.1126/science.705341
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