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Is the Acetylcholine Receptor a Rabies Virus Receptor?
Abstract
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with α-bungarotoxin and d -tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.
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Cited by
Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730
Transvascular delivery of small interfering RNA to the central nervous system
Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246
Human rabies: neuropathogenesis, diagnosis, and management
Hemachudha, T., Ugolini, G., Wacharapluesadee, S., Sungkarat, W., Shuangshoti, S., & Laothamatas, J. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70038-3 · Cited by 446
The cell biology of rabies virus: using stealth to reach the brain
Schnell, M. J., McGettigan, J. P., Wirblich, C., & Papaneri, A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2260 · Cited by 391
A Student’s Guide to Neural Circuit Tracing
Saleeba, C., Dempsey, B., Le, S., Goodchild, A., & McMullan, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00897 · Cited by 153
Metadata
- Authors
- Lentz, T. L., Burrage, T. G., Smith, A. L., Crick, J., & Tignor, G. H.
- Venue
- Science
- Published
- 1982-01-08
- Volume
- 215
- Issue
- 4529
- Pages
- 182-184
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1973895646
- Cited by
- 486
- References
- 0
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Is the Acetylcholine Receptor a Rabies Virus Receptor? https://app.cochat.ai/papers/10.1126/science.7053569
- The paper
- Lentz, T. L., Burrage, T. G., Smith, A. L., Crick, J., & Tignor, G. H. (1982). Is the Acetylcholine Receptor a Rabies Virus Receptor? Science. https://doi.org/10.1126/science.7053569
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
