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Plasminogen Activator Release at the Neuronal Growth Cone
Abstract
The site of plasminogen activator release by differentiated neuroblastoma clonal cell lines was determined with a fibrin overlay assay. Release of plasminogen activator was seen at the growth cone in 72 percent of the cells bearing neurites. For 21 percent of these cells the growth cone was the predominant or exclusive site of this enzyme activity. Selective release of protease at the "trailblazing" tip of the neurite may be important in neuron migration and neurite growth in vivo.
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Cited by
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Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136
Qian, Z., Gilbert, M. E., Colicos, M. A., Kandel, E. R., & Kuhl, D. (1993) · Nature · doi:10.1038/361453a0 · Cited by 870
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
Saksela, O., & Rifkin, D. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.000521 · Cited by 818
Pathophysiology of peripheral nerve injury: a brief review
Burnett, M. G., & Zager, E. L. (2004) · Neurosurgical Focus · doi:10.3171/foc.2004.16.5.2 · Cited by 688
Metadata
- Authors
- Krystosek, A., & Seeds, N. W.
- Venue
- Science
- Published
- 1981-09-25
- Volume
- 213
- Issue
- 4515
- Pages
- 1532-1534
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034299466
- Cited by
- 392
- References
- 0
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
