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Hyperthermia-Induced Seizures in the Rat Pup: A Model for Febrile Convulsions in Children
Abstract
Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.
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Citations
Cited by
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Epilepsy and brain inflammation
Vezzani, A., Aronica, E., Mazarati, A., & Pittman, Q. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.033 · Cited by 603
Thermal biology of the laboratory rat
Gordon, C. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90025-y · Cited by 521
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus
Khazipov, R., Khalilov, I., Tyzio, R., Morozova, E., Ben‐Ari, Y., & Holmes, G. L. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03152.x · Cited by 314
Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis
Schuchmann, S., Schmitz, D., Rivera, C., Vanhatalo, S., Salmen, B., Mackie, K., Sipilä, S. T., Voipio, J., & Kaila, K. (2006) · Nature Medicine · doi:10.1038/nm1422 · Cited by 295
Metadata
- Authors
- Holtzman, D., Obana, K., & Olson, J.
- Venue
- Science
- Published
- 1981-08-28
- Volume
- 213
- Issue
- 4511
- Pages
- 1034-1036
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065813782
- Cited by
- 161
- References
- 0
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hyperthermia-Induced Seizures in the Rat Pup: A Model for Febrile Convulsions in Children. https://app.cochat.ai/papers/10.1126/science.7268407
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- Holtzman, D., Obana, K., & Olson, J. (1981). Hyperthermia-Induced Seizures in the Rat Pup: A Model for Febrile Convulsions in Children. Science. https://doi.org/10.1126/science.7268407
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
