The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Giant Synaptic Potential Hypothesis for Epileptiform Activity
Abstract
According to one hypothesis, the paroxysmal depolarizing shift observed in the penicillin model of epilepsy results from a giant excitatory postsynaptic potential. This hypothesis has recently been questioned, primarily because it has never been subjected to rigorous experimental examination. Four quantitative predictions were derived from this hypothesis and tested in CA3 pyramidal neurons of the hippocampus. The four critical predictions concern the behavior of the paroxysmal depolarizing shift under current- and voltage-clamp conditions as a function of membrane potential. The experiments confirmed all four predictions.
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Citations
Cites
Cortical cellular phenomena in experimental epilepsy: Interictal manifestations
Matsumoto, H., & Marsan, C. A. (1964) · Experimental Neurology · doi:10.1016/0014-4886(64)90025-1 · Cited by 832
Ayala, G. F., Dichter, M. A., Gumnit, R. J., Matsumoto, H., & Spencer, W. A. (1973) · Brain Research · doi:10.1016/0006-8993(73)90647-1 · Cited by 436
Cellular and field potential properties of epileptogenic hippocampal slices
Schwartzkroin, P. A., & Prince, D. A. (1978) · Brain Research · doi:10.1016/0006-8993(78)90776-x · Cited by 433
Prince, D. A. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.002143 · Cited by 392
Voltage clamp discloses slow inward current in hippocampal burst-firing neurones
Johnston, D., Hablitz, J. J., & Wilson, W. A. (1980) · Nature · doi:10.1038/286391a0 · Cited by 246
Self-citationMechanisms underlying epileptiform burst discharge
Schwartzkroin, P. A., & Wyler, A. R. (1980) · Annals of Neurology · doi:10.1002/ana.410070202 · Cited by 231
Passive cable properties of hippocampal CA3 pyramidal neurons
Johnston, D. (1981) · Cellular and Molecular Neurobiology · doi:10.1007/bf00736038 · Cited by 200
Self-citationSpontaneous miniature synaptic potentials in hippocampal neurons
Brown, T. H., Wong, R. K. S., & Prince, D. A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90931-4 · Cited by 80
Self-citation
Cited by
Two-stage model of memory trace formation: A role for “noisy” brain states
Buzsáki, G. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90423-5 · Cited by 1,709
Devinsky, O., Vezzani, A., O'Brien, T. J., Jette, N., Scheffer, I. E., de Curtis, M., & Perucca, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.24 · Cited by 959
Cellular and molecular basis of epilepsy
McNamara, J. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03413.1994 · Cited by 649
Impact of Network Activities on Neuronal Properties in Corticothalamic Systems
Steriade, M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.1 · Cited by 537
Interictal spikes in focal epileptogenesis
de Curtis, M., & Avanzini, G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00026-5 · Cited by 477
Metadata
- Authors
- Johnston, D., & Brown, T. H.
- Venue
- Science
- Published
- 1981-01-16
- Volume
- 211
- Issue
- 4479
- Pages
- 294-297
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1973050784
- Cited by
- 368
- References
- 8
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
