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Functional Isolation and Characterization of Human Hematopoietic Stem Cells
Abstract
Hematopoietic cells differentiate in steps marked by the acquisition or loss of specific phenotypic characteristics. Human bone marrow cells that were responsive to the early-acting cytokines Kit ligand and interleukin-3 were forced to a metabolic death. The subfraction remaining represented 1 in 10(5) bone marrow mononuclear cells, was determined to be quiescent by cell cycle analysis, and had a stem cell immunophenotype. The cells were highly enriched for long-term culture-initiating cells, were capable of secondary colony formation, and produced both myeloid and lymphoid progeny. Thus, this technically simple strategy led to the efficient purification of cells with characteristics of hematopoietic stem cells.
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Cited by
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Self-citationDemaison, C., Parsley, K., Brouns, G., Scherr, M., Battmer, K., Kinnon, C., Grez, M., & Thrasher, A. J. (2002) · Human Gene Therapy · doi:10.1089/10430340252898984 · Cited by 486
Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T., & Tenen, D. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4301 · Cited by 466
Self-citationExtensive Amplification and Self-Renewal of Human Primitive Hematopoietic Stem Cells From Cord Blood
Piacibello, W., Sanavio, F., Garetto, L., Severino, A., Bergandi, D., Ferrario, J., Fagioli, F., Berger, M., & Aglietta, M. (1997) · Blood · doi:10.1182/blood.v89.8.2644 · Cited by 435
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
Kimura, S., Roberts, A. W., Metcalf, D., & Alexander, W. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1195 · Cited by 391
Metadata
- Authors
- Berardi, A. C., Wang, A., Levine, J. D., Lopez, P., & Scadden, D. T.
- Venue
- Science
- Published
- 1995-01-06
- Volume
- 267
- Issue
- 5194
- Pages
- 104-108
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041972573
- Cited by
- 372
- References
- 0
- FWCI
- 27.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berardi, A. C., Wang, A., Levine, J. D., Lopez, P., & Scadden, D. T. (1995). Functional Isolation and Characterization of Human Hematopoietic Stem Cells. Science. https://doi.org/10.1126/science.7528940
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
