The DOI matches its Crossref record.
Molecular Identification of an IgE-Dependent Histamine-Releasing Factor
Abstract
An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.
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Cited by
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Rinnerthaler, M., Jarolim, S., Heeren, G., Palle, E., Perju, S., Klinger, H., Bogengruber, E., Madeo, F., Braun, R. J., Breitenbach-Koller, L., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.022 · Cited by 101
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Metadata
- Authors
- MacDonald, S. M., Rafnar, T., Langdon, J., & Lichtenstein, L. M.
- Venue
- Science
- Published
- 1995-08-04
- Volume
- 269
- Issue
- 5224
- Pages
- 688-690
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012288686
- Cited by
- 365
- References
- 0
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacDonald, S. M., Rafnar, T., Langdon, J., & Lichtenstein, L. M. (1995). Molecular Identification of an IgE-Dependent Histamine-Releasing Factor. Science. https://doi.org/10.1126/science.7542803
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