The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Conformation and Function of the N-Linked Glycan in the Adhesion Domain of Human CD2
Abstract
The adhesion domain of human CD2 bears a single N-linked carbohydrate. The solution structure of a fragment of CD2 containing the covalently bound high-mannose N-glycan [-(N- N -acetylglucosamine) 2 -(mannose) 5-8 ] was solved by nuclear magnetic resonance. The stem and two of three branches of the carbohydrate structure are well defined and the mobility of proximal glycan residues is restricted. Mutagenesis of all residues in the vicinity of the glycan suggests that the glycan is not a component of the CD2-CD58 interface; rather, the carbohydrate stabilizes the protein fold by counterbalancing an unfavorable clustering of five positive charges centered about lysine-61 of CD2.
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Cites
Arulanandam, A. R., Withka, J. M., Wyss, D. F., Wagner, G., Kister, A., Pallai, P., Recny, M. A., & Reinherz, E. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11613 · Cited by 85
Self-citation
Cited by
Petrescu, A.-J. (2003) · Glycobiology · doi:10.1093/glycob/cwh008 · Cited by 469
The structure and ligand interactions of CD2: implications for T-cell function
Davis, S. J., & van der Merwe, P. A. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80617-7 · Cited by 391
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
Core Fucosylation Regulates Epidermal Growth Factor Receptor-mediated Intracellular Signaling
Wang, X., Gu, J., Ihara, H., Miyoshi, E., Honke, K., & Taniguchi, N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510893200 · Cited by 323
Glycoproteins: glycan presentation and protein-fold stability
Wormald, M. R., & Dwek, R. A. (1999) · Structure · doi:10.1016/s0969-2126(99)80095-1 · Cited by 290
Metadata
- Authors
- Wyss, D. F., Choi, J. S., Li, J., Knoppers, M. H., Willis, K. J., Arulanandam, A. R. N., Smolyar, A., Reinherz, E. L., & Wagner, G.
- Venue
- Science
- Published
- 1995-09
- Volume
- 269
- Issue
- 5228
- Pages
- 1273-1278
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015064119
- Cited by
- 309
- References
- 1
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Conformation and Function of the N-Linked Glycan in the Adhesion Domain of Human CD2. https://app.cochat.ai/papers/10.1126/science.7544493
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- Wyss, D. F., Choi, J. S., Li, J., Knoppers, M. H., Willis, K. J., Arulanandam, A. R. N., Smolyar, A., Reinherz, E. L., & Wagner, G. (1995). Conformation and Function of the N-Linked Glycan in the Adhesion Domain of Human CD2. Science. https://doi.org/10.1126/science.7544493
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
