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Requirement for Src Family Protein Tyrosine Kinases in G 2 for Fibroblast Cell Division
Abstract
The protein tyrosine kinase c-Src is transiently activated at the transition from the G 2 phase to mitosis in the cell cycle of mammalian fibroblasts. Fyn and Yes, the other members of the Src family present in fibroblasts, were also found to be activated at mitosis. In cells microinjected with a neutralizing antibody specific for Src, Fyn, and Yes (anti-cst.1) during G 2 , cell division was inhibited by 75 percent. The block occurred before nuclear envelope breakdown. Antibodies specific for phosphatidylinositol-3 kinase α and phospholipase C-γ1 had no effect. Microinjection of the Src homology 2 (SH2) domain of Fyn was also inhibitory. Functional redundancy between members of the Src family was observed; a Src-specific antibody had no effect in NIH 3T3 cells but inhibited cell division in fibroblasts in which the only functional Src family kinase was Src itself. Thus, Src family kinases and proteins associating with their SH2 domains are required for entry into mitosis.
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Cited by
Yeatman, T. J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1366 · Cited by 1,113
Src family kinases are required for integrin but not PDGFR signal transduction
Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A., & Soriano, P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2459 · Cited by 731
NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src
Yu, X.-M., Askalan, R., Keil, G. J., & Salter, M. W. (1997) · Science · doi:10.1126/science.275.5300.674 · Cited by 608
The interplay between Src family kinases and receptor tyrosine kinases
Bromann, P. A., Korkaya, H., & Courtneidge, S. A. (2004) · Oncogene · doi:10.1038/sj.onc.1208079 · Cited by 454
Self-citationMitotic regulation of the human anaphase-promoting complex by phosphorylation
Kraft, C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg627 · Cited by 425
Metadata
- Authors
- Roche, S., Fumagalli, S., & Courtneidge, S. A.
- Venue
- Science
- Published
- 1995-09-15
- Volume
- 269
- Issue
- 5230
- Pages
- 1567-1569
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020240239
- Cited by
- 249
- References
- 0
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Roche, S., Fumagalli, S., & Courtneidge, S. A. (1995). Requirement for Src Family Protein Tyrosine Kinases in G 2 for Fibroblast Cell Division. Science. https://doi.org/10.1126/science.7545311
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