Common origin of pigment cells
Abstract
The fundamentally diverse vertebrate pigment cells, melanophores, xanthophores, and iridophores, contain pigmentary organelles known, respectively, as melanosomes, pterinosomes, and reflecting platelets. Their pigments are melanins, pteridines, and purines. Mosaic pigment cells containing more than one type of organelle have been observed and mosaic organelles containing more than one type of pigment have been discovered. It is proposed that the various pigment cells are derived from a stem cell that contains a primordial organelle of endoplasmic reticular origin. This primordial organelle can differentiate into any of the known pigmentary organelles.
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Decades ago, it was proposed that melanocytes share a common origin with iridophores and xanthophores from a pigment-restricted precursor, which we would term a chromatoblast (Cbl(late)).
“Decades ago, it was proposed that melanocytes share a common origin with iridophores and xanthophores from a pigment-restricted precursor [15], which we would term a chromatoblast (Cbl(late)).”
From The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor (2021) · cites this paper as [15]
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Petratou, K., Subkhankulova, T., Lister, J. A., Rocco, A., Schwetlick, H., & Kelsh, R. N. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007402 · Cited by 69 · see citing works
Petratou, K., Spencer, S. A., Kelsh, R. N., & Lister, J. A. (2021) · PLOS ONE · doi:10.1371/journal.pone.0244794 · Cited by 55 · see citing works
- Authors
- Bagnara, J. T., Matsumoto, J., Ferris, W., Frost, S. K., Turner, W. A., Tchen, T. T., & Taylor, J. D.
- Affiliations
- University of Arizona (US)
- Keio University (JP)
- Wayne State University (US)
- Venue
- Science
- Published
- 1979-02-02
- Volume
- 203
- Issue
- 4379
- Pages
- 410-415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086784184
- Cited by
- 286
- References
- 0
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 12 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 9 · 2015: 7 · 2014: 1 · 2013: 7 · 2012: 1
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- pigment cells, melanophores, xanthophores, iridophores, melanosomes, melanin, pteridines, purines, stem cell origin, endoplasmic reticulum
- MeSH terms
- Animals, Cell Differentiation, Chromatophores, Endoplasmic Reticulum, Models, Biological, Neural Crest, Organoids, Pigmentation, Pigments, Biological
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