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Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors
Abstract
The Rac guanosine 5′-triphosphate (GTP)-binding proteins regulate oxidant production by phagocytic leukocytes. Two Ste20-related p21-activated kinases (PAKs) were identified as targets of Rac in human neutrophils. Activity of the ∼65- and ∼68-kilodalton PAKs was rapidly stimulated by chemoattractants acting through pertussis toxin-sensitive heterotrimeric GTP-binding proteins (G proteins). Native and recombinant PAKs phosphorylated the p47 phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. The action of PAKs during phagocyte activation by G protein-coupled pathways may contribute to regulation of NADPH oxidase activity.
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WIDMANN, C., GIBSON, S., JARPE, M. B., & JOHNSON, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,729
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Van Aelst, L., & D’Souza-Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358
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Metadata
- Authors
- Knaus, U. G., Morris, S., Dong, H.-J., Chernoff, J., & Bokoch, G. M.
- Venue
- Science
- Published
- 1995-07-14
- Volume
- 269
- Issue
- 5221
- Pages
- 221-223
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021289405
- Cited by
- 402
- References
- 0
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Knaus, U. G., Morris, S., Dong, H.-J., Chernoff, J., & Bokoch, G. M. (1995). Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors. Science. https://doi.org/10.1126/science.7618083
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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