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Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2
Abstract
The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a similar presumptive mid-hindbrain domain. However, mutations in En-1 and En-2 produce different phenotypes. En-1 mutant mice die at birth with a large mid-hindbrain deletion, whereas En-2 mutants are viable, with cerebellar defects. To determine whether these contrasting phenotypes reflect differences in temporal expression or biochemical activity of the En proteins, En-1 coding sequences were replaced with En-2 sequences by gene targeting. This rescued all En-1 mutant defects, demonstrating that the difference between En-1 and En-2 stems from their divergent expression patterns.
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Cited by
Fode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J., & Guillemot, F. (2000) · Genes & Development · doi:10.1101/gad.14.1.67 · Cited by 624
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
Zheng, H., Forgetta, V., Hsu, Y., Estrada, K., Rosello‐Diez, A., Leo, P. J., Dahia, C. L., Park‐Min, K. H., Tobias, J. H., Kooperberg, C., et al. (2015) · Nature · doi:10.1038/nature14878 · Cited by 601
Self-citationCorral, J., Lavenir, I., Impey, H., Warren, A. J., Forster, A., Larson, T. A., Bell, S., McKenzie, A. N. J., King, G., & Rabbitts, T. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81269-6 · Cited by 522
Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation
Minichiello, L., Calella, A. M., Medina, D. L., Bonhoeffer, T., Klein, R., & Korte, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00942-x · Cited by 506
β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
Atit, R., Sgaier, S. K., Mohamed, O. A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L., & Conlon, R. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.449 · Cited by 400
“…contributes to brown fat, dermis, and muscle The fate of cells that express En1 in the mouse central dermomyotome was determined with an allele of En1 with Cre recombinase coding sequences inserted (En1Cre) (Hanks et al., 1995) and the Rosa-floxed Stop-LacZ Reporter allele (RR) (Soriano, 1999).”
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Metadata
- Authors
- Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B., & Joyner, A. L.
- Venue
- Science
- Published
- 1995-08-04
- Volume
- 269
- Issue
- 5224
- Pages
- 679-682
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018834244
- Cited by
- 398
- References
- 0
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2. https://app.cochat.ai/papers/10.1126/science.7624797
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- Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B., & Joyner, A. L. (1995). Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2. Science. https://doi.org/10.1126/science.7624797
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