The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA A Receptors
Abstract
Gamma-aminobutyric acid A (GABA A ) receptors are the principal mediators of synaptic inhibition, and yet when intensely activated, dendritic GABA A receptors excite rather than inhibit neurons. The membrane depolarization mediated by GABA A receptors is a result of the differential, activity-dependent collapse of the opposing concentration gradients of chloride and bicarbonate, the anions that permeate the GABA A ionophore. Because this depolarization diminishes the voltage-dependent block of the N -methyl-D-aspartate (NMDA) receptor by magnesium, the activity-dependent depolarization mediated by GABA is sufficient to account for frequency modulation of synaptic NMDA receptor activation. Anionic gradient shifts may represent a mechanism whereby the rate and coherence of synaptic activity determine whether dendritic GABA A receptor activation is excitatory or inhibitory.
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
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Buhl, E. H., Halasy, K., & Somogyi, P. (1994) · Nature · doi:10.1038/368823a0 · Cited by 728
GABAB autoreceptors regulate the induction of LTP
Davies, C. H., Starkey, S. J., Pozza, M. F., & Collingridge, G. L. (1991) · Nature · doi:10.1038/349609a0 · Cited by 615
Cited by
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i · Cited by 3,441
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Owens, D. F., Boyce, L. H., Davis, M. B. E., & Kriegstein, A. R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06414.1996 · Cited by 721
Metadata
- Authors
- Staley, K. J., Soldo, B. L., & Proctor, W. R.
- Venue
- Science
- Published
- 1995-08-18
- Volume
- 269
- Issue
- 5226
- Pages
- 977-981
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971931358
- Cited by
- 781
- References
- 4
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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