The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase
Abstract
Tyrosine phosphorylation of proteins is required for signal transduction in cells and for growth regulation. A mitogen-induced gene ( PAC-1 ) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells.
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Cites
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Cited by
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Metadata
- Authors
- Rohan, P. J., Davis, P., Moskaluk, C. A., Kearns, M., Krutzsch, H., Siebenlist, U., & Kelly, K.
- Venue
- Science
- Published
- 1993-03-19
- Volume
- 259
- Issue
- 5102
- Pages
- 1763-1766
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979881407
- Cited by
- 290
- References
- 16
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rohan, P. J., Davis, P., Moskaluk, C. A., Kearns, M., Krutzsch, H., Siebenlist, U., & Kelly, K. (1993). PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase. Science. https://doi.org/10.1126/science.7681221
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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