The DOI matches its Crossref record.
Increased Activity of L-Type Ca 2+ Channels Exposed to Serum from Patients with Type I Diabetes
Abstract
Type I diabetes [insulin-dependent diabetes mellitus (IDDM)] is an autoimmune disease associated with the destruction of pancreatic β cells. Serum from patients with IDDM increased L-type calcium channel activity of insulin-producing cells and of GH 3 cells derived from a pituitary tumor. The subsequent increase in the concentration of free cytoplasmic Ca 2+ ([Ca 2+ ] i ) was associated with DNA fragmentation typical of programmed cell death or apoptosis. These effects of the serum were prevented by adding a blocker of voltage-activated L-type Ca 2+ channels. When the serum was depleted of immunoglobulin M (IgM), it no longer affected [Ca 2+ ] i . An IgM-mediated increase in Ca 2+ influx may thus be part of the autoimmune reaction associated with IDDM and contribute to the destruction of β cells in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Self-citationThe Role of Calcium in the Regulation of Apoptosis
McConkey, D. J., & Orrenius, S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7409 · Cited by 462
Self-citationInflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes
Donath, M. Y., St�rling, J., Maedler, K., & Mandrup-Poulsen, T. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0450-y · Cited by 422
Glucose and Tolbutamide Induce Apoptosis in Pancreatic β-Cells
Efanova, I. B., Zaitsev, S. V., Zhivotovsky, B., Köhler, M., Efendić, S., Orrenius, S., & Berggren, P.-O. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33501 · Cited by 364
Self-citationCalcium-channel blockade and incidence of cancer in aged populations
Pahor, M., Guralnik, J. M., Ferrucci, L., Corti, M.-C., Salive, M. E., Cerhan, J. R., Wallace, R. B., & Havlik, R. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04277-8 · Cited by 340
Metadata
- Authors
- Juntti-Berggren, L., Larsson, O., Rorsman, P., Ämmälä, C., Bokvist, K., Wåhlander, K., Nicotera, P., Dypbukt, J., Orrenius, S., Hallberg, A., & Berggren, P.-O.
- Venue
- Science
- Published
- 1993-07-02
- Volume
- 261
- Issue
- 5117
- Pages
- 86-90
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981547910
- Cited by
- 187
- References
- 0
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increased Activity of L-Type Ca 2+ Channels Exposed to Serum from Patients with Type I Diabetes. https://app.cochat.ai/papers/10.1126/science.7686306
- The paper
- Juntti-Berggren, L., Larsson, O., Rorsman, P., Ämmälä, C., Bokvist, K., Wåhlander, K., Nicotera, P., Dypbukt, J., Orrenius, S., Hallberg, A., & Berggren, P.-O. (1993). Increased Activity of L-Type Ca 2+ Channels Exposed to Serum from Patients with Type I Diabetes. Science. https://doi.org/10.1126/science.7686306
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
