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Mercury-199 NMR of the Metal Receptor Site in MerR and Its Protein-DNA Complex
Abstract
Structural insights have been provided by mercury-199 nuclear magnetic resonance (NMR) into the metal receptor site of the MerR metalloregulatory protein alone and in a complex with the regulatory target, DNA. The one- and two-dimensional NMR data are consistent with a trigonal planar Hg-thiolate coordination environment consisting only of Cys side chains and resolve structural aspects of both metal ion recognition and the allosteric mechanism. These studies establish 199 Hg NMR techniques as useful probes of the metal coordination environment of regulatory proteins, copper enzymes, and zinc transcription factor complexes as large as 50 kilodaltons.
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Citations
Cited by
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Bruins, M. R., Kapil, S., & Oehme, F. W. (2000) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1999.1860 · Cited by 1,445
Bacterial mercury resistance from atoms to ecosystems
Barkay, T., Miller, S. M., & Summers, A. O. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00046-9 · Cited by 1,054
Metal ion chaperone function of the soluble Cu(I) receptor Atx1.
Pufahl, R. A., Singer, C. P., Peariso, K. L., Lin, S.-J., Schmidt, P. J., Fahrni, C. J., Culotta, V. C., Penner-Hahn, J. E., & O'Halloran, T. V. (1997) · Science · doi:10.1126/science.278.5339.853 · Cited by 691
Self-citationCoordination Chemistry of Bacterial Metal Transport and Sensing
Ma, Z., Jacobsen, F. E., & Giedroc, D. P. (2009) · Chemical Reviews · doi:10.1021/cr900077w · Cited by 621
Protein Design: Toward Functional Metalloenzymes
Yu, F., Cangelosi, V. M., Zastrow, M. L., Tegoni, M., Plegaria, J. S., Tebo, A. G., Mocny, C. S., Ruckthong, L., Qayyum, H., & Pecoraro, V. L. (2014) · Chemical Reviews · doi:10.1021/cr400458x · Cited by 441
Metadata
- Authors
- Utschig, L. M., Bryson, J. W., & O'Halloran, T. V.
- Venue
- Science
- Published
- 1995-04-21
- Volume
- 268
- Issue
- 5209
- Pages
- 380-385
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020081833
- Cited by
- 183
- References
- 0
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mercury-199 NMR of the Metal Receptor Site in MerR and Its Protein-DNA Complex. https://app.cochat.ai/papers/10.1126/science.7716541
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- Utschig, L. M., Bryson, J. W., & O'Halloran, T. V. (1995). Mercury-199 NMR of the Metal Receptor Site in MerR and Its Protein-DNA Complex. Science. https://doi.org/10.1126/science.7716541
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
