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Role of the Chaperone Protein Hsp104 in Propagation of the Yeast Prion-Like Factor [ psi + ]
Abstract
The yeast non-Mendelian factor [ psi + ] has been suggested to be a self-modified protein analogous to mammalian prions. Here it is reported that an intermediate amount of the chaperone protein Hsp104 was required for the propagation of the [ psi + ] factor. Overproduction or inactivation of Hsp104 caused the loss of [ psi + ]. These results suggest that chaperone proteins play a role in prion-like phenomena, and that a certain level of chaperone expression can cure cells of prions without affecting viability. This may lead to antiprion treatments that involve the alteration of chaperone amounts or activity.
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Citations
Cited by
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
Auluck, P. K., Chan, H. Y. E., Trojanowski, J. Q., Lee, V. M.-Y., & Bonini, N. M. (2002) · Science · doi:10.1126/science.1067389 · Cited by 1,227
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
Prasad, A., Bharathi, V., Sivalingam, V., Girdhar, A., & Patel, B. K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00025 · Cited by 774
Prions as adaptive conduits of memory and inheritance
Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1616 · Cited by 555
Self-citationJana, N. R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.13.2009 · Cited by 432
Metadata
- Authors
- Chernoff, Y. O., Lindquist, S. L., Ono, B.-I., Inge-Vechtomov, S. G., & Liebman, S. W.
- Venue
- Science
- Published
- 1995-05-12
- Volume
- 268
- Issue
- 5212
- Pages
- 880-884
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000204824
- Cited by
- 1,027
- References
- 0
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chernoff, Y. O., Lindquist, S. L., Ono, B.-I., Inge-Vechtomov, S. G., & Liebman, S. W. (1995). Role of the Chaperone Protein Hsp104 in Propagation of the Yeast Prion-Like Factor [ psi + ]. Science. https://doi.org/10.1126/science.7754373
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
