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The control of calcium release in heart muscle
Abstract
The control of calcium release from intracellular stores (the sarcoplasmic reticulum) in cardiac muscle was examined with the use of a confocal microscope and voltage clamp techniques. Depolarization evoked graded calcium release by altering the extent of spatial and temporal summation of elementary calcium release events called "calcium sparks." These evoked sparks were triggered by local L-type calcium channel currents in a stochastic manner, were similar at different potentials, and resembled spontaneous calcium sparks. Once triggered, the calcium release from the sarcoplasmic reticulum during a calcium spark was independent of the duration of the triggering calcium influx. These results were used to develop a unifying model for cardiac excitation-contraction coupling that explains the large (but paradoxically stable) amplification of the trigger calcium influx by a combination of digital and analog behavior.
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Cited by
The machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Use of thapsigargin to study Ca2+ homeostasis in cardiac cells
Rogers, T. B., Inesi, G., Wade, R., & Lederer, W. J. (1995) · Bioscience Reports · doi:10.1007/bf01788366 · Cited by 147
Self-citationCalcium-induced release of calcium in muscle: 50 years of work and the emerging consensus
Ríos, E. (2018) · Journal of General Physiology · doi:10.1085/jgp.201711959 · Cited by 103
Metadata
- Authors
- Cannell, M., Cheng, H., & Lederer, W.
- Venue
- Science
- Published
- 1995-05-19
- Volume
- 268
- Issue
- 5213
- Pages
- 1045-1049
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021647551
- Cited by
- 550
- References
- 0
- FWCI
- 38.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The control of calcium release in heart muscle. https://app.cochat.ai/papers/10.1126/science.7754384
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- Cannell, M., Cheng, H., & Lederer, W. (1995). The control of calcium release in heart muscle. Science. https://doi.org/10.1126/science.7754384
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
