The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
Abstract
Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing βARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of β-adrenergic receptors. Conversely, mice expressing the βARK inhibitor displayed enhanced cardiac contractility in vivo with or without isoproterenol. These animals demonstrate the important role of βARK in modulating in vivo myocardial function. Because increased amounts of βARK1 and diminished cardiac β-adrenergic responsiveness characterize heart failure, these animals may provide experimental models to study the role of βARK in heart disease.
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Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cited by
Seven-transmembrane-spanning receptors and heart function
Rockman, H. A., Koch, W. J., & Lefkowitz, R. J. (2002) · Nature · doi:10.1038/415206a · Cited by 938
Self-citationBernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 894
Mechanisms and Models in Heart Failure: A Combinatorial Approach
Mann, D. L. (1999) · Circulation · doi:10.1161/01.cir.100.9.999 · Cited by 773
Animal Models of Heart Failure: A Scientific Statement From the American Heart Association
Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research · doi:10.1161/res.0b013e3182582523 · Cited by 435
Self-citationG-protein-coupled receptors: turn-ons and turn-offs
Carman, C. V., & Benovic, J. L. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80058-5 · Cited by 294
Metadata
- Authors
- Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R., Bond, R. A., Milano, C. A., & Lefkowitz, R. J.
- Venue
- Science
- Published
- 1995-06-02
- Volume
- 268
- Issue
- 5215
- Pages
- 1350-1353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043698693
- Cited by
- 719
- References
- 1
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R., Bond, R. A., Milano, C. A., & Lefkowitz, R. J. (1995). Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor. Science. https://doi.org/10.1126/science.7761854
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
