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Reconstitution of Transcription Factor SL1: Exclusive Binding of TBP by SL1 or TFIID Subunits
Abstract
RNA polymerase I and II transcription factors SL1 and TFIID, respectively, are composed of the TATA-binding protein (TBP) and a set of TBP-associated factors (TAFs) responsible for promoter recognition. How the universal transcription factor TBP becomes committed to a TFIID or SL1 complex has not been known. Complementary DNAs encoding each of the three TAF I s that are integral components of SL1 have now been isolated. Analysis of subunit interactions indicated that the three TAF I s can bind individually and specifically to TBP. In addition, these TAF I s interact with each other to form a stable TBP-TAF complex. When TBP was bound first by either TAF I 110, 63, or 48, subunits of TFIID such as TAF II 250 and 150 did not bind TBP. Conversely, if TBP first formed a complex with TAF II 250 or 150, the subunits of SL1 did not bind TBP. These results suggest that a mutually exclusive binding specificity for TBP intrinsic to SL1 and TFIID subunits directs the formation of promoter- and RNA polymerase-selective TBP-TAF complexes.
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Metadata
- Authors
- Comai, L., Zomerdijk, J. C. B. M., Beckmann, H., Zhou, S., Admon, A., & Tjian, R.
- Venue
- Science
- Published
- 1994-12-23
- Volume
- 266
- Issue
- 5193
- Pages
- 1966-1972
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026015266
- Cited by
- 247
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Comai, L., Zomerdijk, J. C. B. M., Beckmann, H., Zhou, S., Admon, A., & Tjian, R. (1994). Reconstitution of Transcription Factor SL1: Exclusive Binding of TBP by SL1 or TFIID Subunits. Science. https://doi.org/10.1126/science.7801123
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